Ser348
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Home > Phosphorylation Site Page: > Ser348  -  NHERF (dog)

Site Information
ERAHQKRssKRAPQM   SwissProt
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455752

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
HaCaT (keratinocyte) ( 1 ) , MDCK (epithelial) ( 1 )

Upstream Regulation
Regulatory protein:
PPP1CA (human) ( 1 )
Putative in vivo kinases:
PKCA (human) ( 1 )
Kinases, in vitro:
PKCA (human) ( 1 )
Treatments:
calyculin_A ( 1 ) , cell_detachment ( 1 ) , Go_6976 ( 1 ) , phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on NHERF:
enzymatic activity, inhibited ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Inhibit interaction with:
ARHGEF7 (human) ( 1 ) , Ezrin (human) ( 1 )

References 

1

Chen JY, Lin YY, Jou TS (2012) Phosphorylation of EBP50 negatively regulates β-PIX-dependent Rac1 activity in anoikis. Cell Death Differ 19, 1027-37
22301917   Curated Info

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