Ser63
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Home > Phosphorylation Site Page: > Ser63  -  SREBP-1 (human)

Site Information
AGGtDPAsPDTSSPG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 23940711

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , hepatic ( 1 ) , HepG2 (hepatic) ( 1 )

Upstream Regulation
Regulatory protein:
MKK3 (human) ( 1 )
Putative in vivo kinases:
P38A (human) ( 1 )
Kinases, in vitro:
P38A (human) ( 1 ) , P38B (human) ( 1 ) , P38G (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Kotzka J, et al. (2012) Preventing Phosphorylation of Sterol Regulatory Element-Binding Protein 1a by MAP-Kinases Protects Mice from Fatty Liver and Visceral Obesity. PLoS One 7, e32609
22384276   Curated Info