Thr776
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Home > Phosphorylation Site Page: > Thr776  -  CdGAP (mouse)

Site Information
tPAPPPPtPLEEEPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456517

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 2 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 3 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 2 ) , COS (fibroblast) ( 2 , 3 ) , HEK293T (epithelial) ( 1 ) , MDCK (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 3 ) , GSK3A (human) ( 2 ) , GSK3B (human) ( 2 )
Kinases, in vitro:
ERK1 (human) ( 3 ) , GSK3A (human) ( 2 ) , GSK3B (human) ( 2 )
Treatments:
AR-A014418 ( 2 ) , lithium ( 2 ) , SB415286 ( 2 ) , serum_starvation ( 2 )

Downstream Regulation
Effects of modification on CdGAP:
activity, inhibited ( 1 , 3 )
Effects of modification on biological processes:
transcription, altered ( 2 )

References 

1

Togawa A, et al. (2010) Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent tight junction disassembly. Biochem Biophys Res Commun 400, 271-7
20728428   Curated Info

2

Danek EI, et al. (2007) Glycogen synthase kinase-3 phosphorylates CdGAP at a consensus ERK 1 regulatory site. J Biol Chem 282, 3624-31
17158447   Curated Info

3

Tcherkezian J, et al. (2005) Extracellular signal-regulated kinase 1 interacts with and phosphorylates CdGAP at an important regulatory site. Mol Cell Biol 25, 6314-29
16024771   Curated Info

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