Thr655
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Home > Phosphorylation Site Page: > Thr655  -  PKCG (human)

Site Information
TRAAPALtPPDRLVL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456511

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 ) , phospho-antibody ( 5 )
Disease tissue studied:
FTLD ( 2 ) , spinocerebellar ataxia type 14 ( 5 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 2 ) , A498 (renal) ( 3 ) , HeLa S3 (cervical) ( 4 )

Upstream Regulation
Treatments:
aggregation ( 5 )

Disease / Diagnostics Relevance
Relevant diseases:
spinocerebellar ataxia type 14 ( 5 )

References 

1

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

2

Herskowitz JH, et al. (2010) Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration. J Proteome Res 9, 6368-79
20886841   Curated Info

3

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

4

Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48
18691976   Curated Info

5

Seki T, et al. (2005) Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death. J Biol Chem 280, 29096-106
15964845   Curated Info