Ser1490
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Home > Phosphorylation Site Page: > Ser1490  -  LRP6 (mouse)

Site Information
AILNPPPsPAtERSH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456289

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 4 , 5 , 6 ) , phospho-antibody ( 7 , 8 ) , western blotting ( 7 , 8 )
Disease tissue studied:
bone cancer ( 7 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 1 ) , epithelial ( 8 ) , liver ( 5 ) , liver [leptin (mouse), homozygous knockout] ( 5 ) , MEF (fibroblast) ( 4 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 6 ) , Rat1 (fibroblast) ( 7 ) , Saos-2 (bone cell) ( 7 )

Upstream Regulation
Regulatory protein:
axin 1 (mouse) ( 7 ) , DVL1 (mouse) ( 7 ) , SHISA2 (mouse) ( 7 )
Treatments:
CHIR99021 ( 3 ) , HGF ( 3 ) , lithium ( 3 ) , PHA-665752 ( 3 ) , Wnt3a ( 3 , 7 ) , Wnt5a ( 7 )

References 

1

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Koraishy FM, et al. (2014) Hepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling. J Biol Chem 289, 14341-50
24692544   Curated Info

4

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

5

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

6

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

7

Grumolato L, et al. (2010) Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev 24, 2517-30
21078818   Curated Info

8

Nava P, et al. (2010) Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32, 392-402
20303298   Curated Info