Thr134
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Home > Phosphorylation Site Page: > Thr134  -  MAFA (human)

Site Information
NPEALNLtPEDAVEA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456029

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:
pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
P38A (human) ( 1 )
Treatments:
SB203580 ( 1 )

Downstream Regulation
Effects of modification on MAFA:
protein degradation ( 1 , 2 )

References 

1

El Khattabi I, Sharma A (2013) Preventing p38 MAPK-Mediated MafA Degradation Ameliorates β-Cell Dysfunction under Oxidative Stress. Mol Endocrinol 27, 1078-90
23660596   Curated Info

2

Kondo T, et al. (2009) p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol 23, 1281-90
19407223   Curated Info