Ser235
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser235  -  p73 (human)

Site Information
DPVTGRQsVVVPYEP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 23481800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , breast cancer ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 1 )
Kinases, in vitro:
AurA (human) ( 1 )
Treatments:
cisplatin ( 1 ) , MLN8054 ( 1 )

Downstream Regulation
Effects of modification on p73:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , cell cycle regulation ( 1 ) , cell growth, induced ( 1 ) , transcription, inhibited ( 1 )
Induce interaction with:
HSPA9B (human) ( 1 )
Inhibit interaction with:
CDC20 (human) ( 1 ) , DNA ( 1 )

References 

1

Katayama H, et al. (2012) Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell 21, 196-211
22340593   Curated Info