Ser74
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Home > Phosphorylation Site Page: > Ser74  -  DCK (mouse)

Site Information
EFEELTtsQKSGGNV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456305
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 3 , 4 , 5 , 6 , 7 , 8 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
anthrax infection ( 4 ) , leukemia ( 2 ) , chronic lymphocytic leukemia ( 2 )
Relevant cell line - cell type - tissue:
'brain, embryonic' ( 8 ) , 'stem, embryonic' ( 6 ) , L1210 (lymphoblast) ( 2 ) , lung ( 5 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 3 ) , MEF (fibroblast) ( 2 ) , RAW 264.7 (macrophage) ( 1 ) , spleen ( 4 , 5 )

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 2 )
Kinases, in vitro:
ATM (human) ( 2 )
Treatments:
ionizing_radiation ( 2 ) , KU-55933 ( 2 ) , NU7441 ( 2 )

Downstream Regulation
Effects of modification on DCK:
activity, induced ( 2 ) , enzymatic activity, induced ( 2 )
Effects of modification on biological processes:
DNA repair, induced ( 2 ) , signaling pathway regulation ( 2 )

References 

1

Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44
25367039   Curated Info

2

Bunimovich YL, et al. (2014) Deoxycytidine Kinase Augments ATM-Mediated DNA Repair and Contributes to Radiation Resistance. PLoS One 9, e104125
25101980   Curated Info

3

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

4

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

5

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

6

Tucker M (2010) CST Curation Set: 9076; Year: 2010; Biosample/Treatment: cell line, embryonic stem cells (mouse)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) ATM/ATR Substrate Antibody (polyAB) Cat#: 3005, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQ) Immunoaffinity Beads Cat#: 1980
Curated Info

7

Rikova K (2008) CST Curation Set: 5296; Year: 2008; Biosample/Treatment: cell line, Dana Farber-KTL(LN)-4/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q
Curated Info

8

Guo A (2007) CST Curation Set: 2677; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851
Curated Info

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