Tyr155
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr155  -  PKCD (human)

Site Information
IKQAKIHyIKNHEFI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447575

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 )
Relevant cell line - cell type - tissue:
platelet-blood ( 3 ) , U87MG (glial) ( 1 )

Upstream Regulation
Treatments:
bryostatin_1 ( 2 ) , collagen ( 3 ) , Hypericin ( 1 ) , ionizing_radiation ( 2 ) , light ( 1 ) , PAR1-activating_peptide ( 3 ) , PAR4-activating_peptide ( 3 ) , thrombin ( 3 ) , vanadate ( 3 )

Downstream Regulation
Effects of modification on PKCD:
intracellular localization ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 )

References 

1

Misuth M, et al. (2017) The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells. Cell Signal 34, 11-22
28237688   Curated Info

2

Dagur RS, Hambarde S, Chandna S (2015) Bryostatin-1 causes radiosensitization of BMG-1 malignant glioma cells through differential activation of protein kinase-Cδ not evident in the non-malignant AA8 fibroblasts. Mol Cell Biochem 401, 49-59
25472878   Curated Info

3

Hall KJ, Jones ML, Poole AW (2007) Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling. Biochem J 406, 501-9
17570831   Curated Info