Thr94
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Home > Phosphorylation Site Page: > Thr94  -  DYNLT1 (mouse)

Site Information
SSTDGSCtVRWENkT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456225

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 1 ) , HEK293T (epithelial) ( 2 ) , hTERT-RPE1 (epithelial) ( 1 ) , neuron-'brain, cerebral cortex' ( 1 )

Upstream Regulation
Treatments:
antibody ( 1 ) , IGF-1 ( 1 )

Downstream Regulation
Effects of modification on DYNLT1:
activity, induced ( 1 ) , intracellular localization ( 1 , 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , cell differentiation, induced ( 1 ) , cell growth, induced ( 1 ) , cytoskeletal reorganization ( 2 )
Induce interaction with:
ARHGEF2 (mouse) ( 2 )
Inhibit interaction with:
DYNC1I1 (mouse) ( 2 )

References 

1

Yeh C, et al. (2013) IGF-1 Activates a Cilium-Localized Noncanonical Gβγ Signaling Pathway that Regulates Cell-Cycle Progression. Dev Cell 26, 358-68
23954591   Curated Info

2

Meiri D, et al. (2012) Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition. Mol Cell 45, 642-55
22405273   Curated Info