Thr94
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Home > Phosphorylation Site Page: > Thr94  -  DYNLT1 (human)

Site Information
SSTDGSCtVRWENKT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456225

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 , 4 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 3 , 4 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 4 ) , 293 (epithelial) ( 1 , 2 ) , 3T3 (fibroblast) ( 3 , 4 ) , hTERT-RPE1 (epithelial) ( 3 , 4 ) , neuron-'brain, cerebral cortex' ( 3 ) , RPE-1 (retinal) ( 1 )

Upstream Regulation
Putative in vivo kinases:
MAST4 (human) ( 1 )
Treatments:
serum ( 1 , 4 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on DYNLT1:
activity, induced ( 4 ) , intracellular localization ( 1 , 3 , 4 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 3 , 4 ) , cell differentiation, induced ( 3 ) , cell growth, induced ( 3 , 4 ) , cytoskeletal reorganization ( 1 , 4 )
Inhibit interaction with:
TIM-1 (human) ( 2 )

References 

1

Sakaji K, et al. (2023) MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1. Life Sci Alliance 6
37726137   Curated Info

2

Ismail OZ, et al. (2018) Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis. J Cell Physiol
29693725   Curated Info

3

Yeh C, et al. (2013) IGF-1 Activates a Cilium-Localized Noncanonical Gβγ Signaling Pathway that Regulates Cell-Cycle Progression. Dev Cell 26, 358-68
23954591   Curated Info

4

Li A, et al. (2011) Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors. Nat Cell Biol 13, 402-11
21394082   Curated Info