Ser438
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Home > Phosphorylation Site Page: > Ser438  -  TAB1 (human)

Site Information
tPTLTNQsPTLtLQS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456224

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 7 ) , immunoprecipitation ( 5 ) , mass spectrometry ( 2 ) , mutation of modification site ( 7 ) , phospho-antibody ( 5 , 6 , 8 ) , western blotting ( 5 , 6 , 8 )
Disease tissue studied:
cervical cancer ( 8 ) , cervical squamous cell carcinoma ( 8 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
JNK1 (human) ( 6 ) , JNK2 (human) ( 6 ) , yopJ (bacteria) ( 7 )
Putative in vivo kinases:
ERK1 (human) ( 6 ) , ERK2 (human) ( 6 ) , JNK1 (human) ( 6 ) , JNK2 (human) ( 6 )
Kinases, in vitro:
P38A (human) ( 8 )
Putative upstream phosphatases:
DUSP14 (human) ( 1 )
Treatments:
anisomycin ( 8 ) , anti-CD3/CD28 ( 1 ) , H2O2 ( 8 ) , IL-1a ( 7 , 8 ) , IL-1b ( 6 ) , ionomycin ( 1 ) , LPS ( 8 ) , PD184352 ( 6 , 8 ) , phorbol_ester ( 1 ) , SB203580 ( 7 , 8 ) , sorbitol ( 6 , 8 ) , TNF ( 8 ) , UV ( 8 )

Downstream Regulation
Effects of modification on TAB1:
phosphorylation ( 5 )

References 

1

Yang CY, et al. (2014) Dual-Specificity Phosphatase 14 (DUSP14/MKP6) Negatively Regulates TCR Signaling by Inhibiting TAB1 Activation. J Immunol 192, 1547-57
24403530   Curated Info

2

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

3

Pathak S, et al. (2012) O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. EMBO J 31, 1394-404
22307082   Curated Info

4

Wolf A, et al. (2011) Identification and Functional Characterization of Novel Phosphorylation Sites in TAK1-Binding Protein (TAB) 1. PLoS One 6, e29256
22216226   Curated Info

5

Shin MS, et al. (2009) Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1. Biochim Biophys Acta 1793, 1156-64
19393267   Curated Info

6

Mendoza H, et al. (2008) Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J 409, 711-22
18021073   Curated Info

7

Thiefes A, et al. (2006) The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. EMBO Rep 7, 838-44
16845370   Curated Info

8

Cheung PC, Campbell DG, Nebreda AR, Cohen P (2003) Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. EMBO J 22, 5793-805
14592977   Curated Info