Thr431
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Home > Phosphorylation Site Page: > Thr431  -  TAB1 (human)

Site Information
ASTLDEAtPTLTNQs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456223

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 6 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 5 ) , mutation of modification site ( 6 ) , phospho-antibody ( 4 , 7 ) , western blotting ( 4 , 7 )
Disease tissue studied:
cervical cancer ( 7 ) , cervical squamous cell carcinoma ( 7 ) , leukemia ( 5 ) , chronic myelogenous leukemia ( 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
P38A (human) ( 4 )
Kinases, in vitro:
P38A (human) ( 7 )
Treatments:
anisomycin ( 7 ) , anti-CD3/CD28 ( 1 ) , EGF ( 4 ) , H2O2 ( 7 ) , IL-1a ( 7 ) , ionomycin ( 1 ) , LPS ( 7 ) , PD184352 ( 7 ) , phorbol_ester ( 1 ) , SB203580 ( 4 , 7 ) , sorbitol ( 7 ) , TNF ( 6 , 7 ) , UV ( 7 )

Downstream Regulation
Effects of modification on TAB1:
activity, inhibited ( 6 ) , phosphorylation ( 4 , 6 )

References 

1

Yang CY, et al. (2014) Dual-Specificity Phosphatase 14 (DUSP14/MKP6) Negatively Regulates TCR Signaling by Inhibiting TAB1 Activation. J Immunol 192, 1547-57
24403530   Curated Info

2

Pathak S, et al. (2012) O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. EMBO J 31, 1394-404
22307082   Curated Info

3

Wolf A, et al. (2011) Identification and Functional Characterization of Novel Phosphorylation Sites in TAK1-Binding Protein (TAB) 1. PLoS One 6, e29256
22216226   Curated Info

4

Shin MS, et al. (2009) Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1. Biochim Biophys Acta 1793, 1156-64
19393267   Curated Info

5

Stokes M (2008) CST Curation Set: 4391; Year: 2008; Biosample/Treatment: cell line, K562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

6

Singhirunnusorn P, et al. (2005) Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J Biol Chem 280, 7359-68
15590691   Curated Info

7

Cheung PC, Campbell DG, Nebreda AR, Cohen P (2003) Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. EMBO J 22, 5793-805
14592977   Curated Info