Ser423
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Home > Phosphorylation Site Page: > Ser423  -  TAB1 (human)

Site Information
QMVNGAHsASTLDEA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456222

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 6 ) , immunoprecipitation ( 3 ) , mutation of modification site ( 6 ) , phospho-antibody ( 3 , 4 , 5 , 7 ) , western blotting ( 3 , 4 , 5 , 7 )
Disease tissue studied:
cervical cancer ( 7 ) , cervical squamous cell carcinoma ( 7 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
P38A (human) ( 3 )
Kinases, in vitro:
P38A (human) ( 7 )
Treatments:
anisomycin ( 7 ) , BIRB-0796 ( 4 , 5 ) , EGF ( 3 ) , H2O2 ( 7 ) , IL-1a ( 7 ) , IL-1b ( 5 ) , LPS ( 7 ) , MMS ( 4 ) , PD184352 ( 7 ) , SB203580 ( 3 , 4 , 5 , 7 ) , sorbitol ( 7 ) , TNF ( 6 , 7 ) , UV ( 7 )

Downstream Regulation
Effects of modification on TAB1:
activity, inhibited ( 6 ) , phosphorylation ( 3 , 6 )

References 

1

Pathak S, et al. (2012) O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. EMBO J 31, 1394-404
22307082   Curated Info

2

Wolf A, et al. (2011) Identification and Functional Characterization of Novel Phosphorylation Sites in TAK1-Binding Protein (TAB) 1. PLoS One 6, e29256
22216226   Curated Info

3

Shin MS, et al. (2009) Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1. Biochim Biophys Acta 1793, 1156-64
19393267   Curated Info

4

Klevernic IV, Morton S, Davis RJ, Cohen P (2009) Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage. Biochem J 418, 625-34
19076070   Curated Info

5

Mendoza H, et al. (2008) Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J 409, 711-22
18021073   Curated Info

6

Singhirunnusorn P, et al. (2005) Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J Biol Chem 280, 7359-68
15590691   Curated Info

7

Cheung PC, Campbell DG, Nebreda AR, Cohen P (2003) Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. EMBO J 22, 5793-805
14592977   Curated Info