Ser21
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Home > Phosphorylation Site Page: > Ser21  -  GSK3B (mouse)

Site Information
CkPVQQPsAFGsMKV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456055

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 , 5 ) , western blotting ( 1 , 2 , 3 , 5 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
bone marrow ( 3 ) , liver ( 5 ) , Neuro-2a (neuron) ( 1 ) , stromal ( 3 )

Upstream Regulation
Regulatory protein:
CLEC11A (human) ( 3 ) , PPP2CA (human) ( 1 )
Treatments:
hepatitis C virus expression ( 5 ) , insulin ( 1 ) , PTH ( 3 ) , sanguinarine ( 1 ) , SOSTi ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cell differentiation, induced ( 3 ) , transcription, induced ( 3 )

References 

1

Yadav Y, Dey CS (2023) PP2Cα aggravates neuronal insulin resistance leading to AD-like phenotype in vitro. Biochem Biophys Res Commun 644, 49-54
36630734   Curated Info

2

Pilo CA, et al. (2022) Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition. Sci Signal 15, eabk1147
36166510   Curated Info

3

Zhang J, et al. (2021) The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin. Proc Natl Acad Sci U S A 118
34140410   Curated Info

4

Llorach-Pares L, et al. (2020) Meridianins and Lignarenone B as Potential GSK3¿¿ Inhibitors and Inductors of Structural Neuronal Plasticity. Biomolecules
32326204   Curated Info

5

Lerat H, et al. (2017) Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice. J Biol Chem 292, 12860-12873
28559285   Curated Info

6

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

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