Tyr317
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Home > Phosphorylation Site Page: > Tyr317  -  Syk (rat)

Site Information
STVSFNPyEPTGGAW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447658

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
C4A2 (mast) ( 2 ) , RBL-2H3 (basophil) [Syk (rat), transfection] ( 3 ) , RBL-2H3 (basophil) [transfection] ( 1 )

Upstream Regulation
Regulatory protein:
LYN (rat) ( 1 )
Treatments:
anti-FcR1 ( 1 ) , Bay61-3606 ( 1 ) , BIRA766 ( 1 )

Downstream Regulation
Effects of modification on Syk:
enzymatic activity, inhibited ( 1 , 3 )

References 

1

Sanderson MP, et al. (2010) Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation. Mol Immunol 48, 171-8
20828828   Curated Info

2

de Castro RO, et al. (2010) Tyrosines in the carboxyl terminus regulate syk kinase activity and function. J Biol Chem 285, 26674-84
20554527   Curated Info

3

Sada K, Zhang J, Siraganian RP (2000) Point mutation of a tyrosine in the linker region of Syk results in a gain of function. J Immunol 164, 338-44
10605028   Curated Info