Ser774

Site Information
EGVKRTLsFSLRSGR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 456217

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 , 3 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 )

Upstream Regulation
Kinases, in vitro:	PKACA (cow) ( 3 ) , PKCA (human) ( 2 )

References
1	Spahn V, et al. (2013) Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner. Pain 154, 598-608 23398938 Curated Info
2	Bhave G, et al. (2003) Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci U S A 100, 12480-5 14523239 Curated Info
3	Bhave G, et al. (2002) cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 35, 721-31 12194871 Curated Info