Ser10
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Home > Phosphorylation Site Page: > Ser10  -  SIRT6 (human)

Site Information
VNYAAGLsPYADKGk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 23144710

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 6 ) , mass spectrometry ( 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ) , mutation of modification site ( 1 , 6 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 6 )
Disease tissue studied:
breast cancer ( 5 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 , 5 ) , colorectal cancer, surrounding tissue ( 10 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 6 , 9 ) , breast ( 2 , 5 ) , colon ( 10 ) , HCA2 (fibroblast) ( 1 ) , HeLa (cervical) ( 4 , 8 ) , Jurkat (T lymphocyte) ( 7 )

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 1 )
Kinases, in vitro:
JNK1 (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
DNA repair, induced ( 1 )

References 

1

Van Meter M, et al. (2016) JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Rep 16, 2641-2650
27568560   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Boeing S, et al. (2016) Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep 15, 1597-1610
27184836   Curated Info

4

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

5

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

6

Miteva YV, Cristea IM (2014) A Proteomic Perspective of Sirtuin 6 (SIRT6) Phosphorylation and Interactions and Their Dependence on Its Catalytic Activity. Mol Cell Proteomics 13, 168-83
24163442   Curated Info

7

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

8

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

9

Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501
19413330   Curated Info

10

Li Y (2009) CST Curation Set: 6853; Year: 2009; Biosample/Treatment: tissue, colon/0.1% serum; Disease: colorectal cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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