Thr183
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Home > Phosphorylation Site Page: > Thr183  -  p27Kip1 (mouse)

Site Information
DGsPNAGtVEQtPKK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 23128659

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry (in vitro) ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Nik (human) ( 1 )
Putative in vivo kinases:
IKKA (human) ( 1 )
Kinases, in vitro:
IKKA (mouse) ( 1 )
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on p27Kip1:
intracellular localization ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
breast adenocarcinoma ( 1 )

References 

1

Zhang W, et al. (2013) A NIK-IKK╬▒ Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1. Cancer Cell 23, 647-59
23602409   Curated Info