Ser711

Site Information
ASVLLKHsKADGLAG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 23084522

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 )
Disease tissue studied:	leukemia ( 2 , 3 ) , acute myelogenous leukemia ( 2 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 1 , 2 ) , acute megakaryoblastic leukemia (M7) ( 1 ) , acute monoblastic leukemia (M5a) or acute monocytic leukemia (M5b) ( 1 ) , acute myeloblastic leukemia, with granulocytic maturation (M2) ( 1 ) , chronic myelogenous leukemia ( 3 )
Relevant cell line - cell type - tissue:	AML-193 (monocyte) ( 1 , 2 ) , CMK (megakaryoblast) ( 1 ) , HEL (erythroid) ( 1 , 2 ) , Jurkat (T lymphocyte) ( 4 , 5 ) , K562 (erythroid) ( 3 ) , Kasumi-1 (myeloid) ( 1 ) , KG-1 (myeloid) ( 1 ) , MV4-11 (macrophage) ( 1 , 2 ) , P31/FUJ (erythroid) ( 1 )

Upstream Regulation
Treatments:	MEK_inhibitor_I ( 2 )

References
1	Casado P, et al. (2013) Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors. Genome Biol 14, R37 23628362 Curated Info
2	Alcolea MP, et al. (2012) Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance. Mol Cell Proteomics 11, 453-66 22547687 Curated Info
3	Zhou J (2011) CST Curation Set: 12808; Year: 2011; Biosample/Treatment: cell line, K-562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Curated Info
4	Moritz A (2011) CST Curation Set: 12258; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	Possemato A (2011) CST Curation Set: 11713; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info