Ser367

Site Information
SRIPVSKsQPVtPEK SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 22996308

In vivo Characterization
Methods used to characterize site in vivo:	immunoassay ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:	fibrosarcoma of soft tissue ( 2 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , GM09607 (fibroblast) ( 2 ) , HeLa (cervical) ( 1 , 2 ) , HT1080 (fibroblast) ( 2 ) , IMR-90 (fibroblast) ( 2 )

Downstream Regulation
Effects of modification on TRF1:	intracellular localization ( 1 , 2 ) , molecular association, regulation ( 2 ) , protein degradation ( 2 )
Inhibit interaction with:	DNA ( 2 )

References
1	Tong AS, et al. (2015) ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Rep 13, 1633-46 26586433 Curated Info
2	McKerlie M, Lin S, Zhu XD (2012) ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance. Nucleic Acids Res 40, 3975-89 22266654 Curated Info