Ser463
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Home > Phosphorylation Site Page: > Ser463  -  coronin 1C (human)

Site Information
CNQDERIskLEQQMA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 22996300

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phosphopeptide mapping ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma multiforme ( 1 ) , glioma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 2 )
Kinases, in vitro:
CK2A1 (human) ( 2 )
Treatments:
CK2_activator ( 2 ) , TBB ( 2 )

Downstream Regulation
Effects of modification on biological processes:
cell adhesion, induced ( 1 ) , cell growth, inhibited ( 1 ) , cell motility, inhibited ( 2 ) , cytoskeletal reorganization ( 1 , 2 )

References 

1

Ziemann A, et al. (2013) CRN2 enhances the invasiveness of glioblastoma cells. Neuro Oncol 15, 548-61
23410663   Curated Info

2

Xavier CP, et al. (2012) Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration. Sci Rep 2, 241
22355754   Curated Info