Lys35
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Home > Sumoylation Site Page: > Lys35  -  PIAS4 (human)

Site Information
GRSkSGLkHELVTRA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2293702

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
cervical cancer ( 1 ) , cervical adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on PIAS4:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , sumoylation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Inhibit interaction with:
PML (human) ( 1 )

References 

1

Ihara M, Yamamoto H, Kikuchi A (2005) SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4. Mol Cell Biol 25, 3506-18
15831457   Curated Info