Ser186
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Home > Phosphorylation Site Page: > Ser186  -  14-3-3 sigma (mouse)

Site Information
FHYEIANsPEEAISL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456054

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
imatinib ( 1 , 2 ) , inhibitor_IX ( 2 ) , ionizing_radiation ( 2 ) , RAD001 ( 1 ) , SB202190 ( 2 ) , SP600125 ( 1 )

Downstream Regulation
Effects of modification on 14-3-3 sigma:
molecular association, regulation ( 2 )
Inhibit interaction with:
Abl (mouse) ( 2 )

References 

1

Mancini M, et al. (2010) mTOR inhibitor RAD001 (Everolimus) enhances the effects of imatinib in chronic myeloid leukemia by raising the nuclear expression of c-ABL protein. Leuk Res 34, 641-8
19643477   Curated Info

2

Mancini M, et al. (2009) 14-3-3 ligand prevents nuclear import of c-ABL protein in chronic myeloid leukemia. Traffic 10, 637-47
19220809   Curated Info