Ser186
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Home > Phosphorylation Site Page: > Ser186  -  14-3-3 sigma (human)

Site Information
FHYEIANsPEEAISL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456054

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
colorectal cancer ( 3 ) , colorectal carcinoma ( 3 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 ) , chronic myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 3 )
Kinases, in vitro:
JNK1 (human) ( 3 )
Treatments:
anisomycin ( 3 ) , SP600125 ( 1 , 3 )

Downstream Regulation
Effects of modification on 14-3-3 sigma:
molecular association, regulation ( 1 , 3 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 2 )
Induce interaction with:
JNK1 (human) ( 2 )
Inhibit interaction with:
BAX (human) ( 3 ) , CBY1 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
chronic myelogenous leukemia ( 1 )

References 

1

Mancini M, et al. (2015) 14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia. PLoS One 10, e0131074
26147002   Curated Info

2

Sunayama J, Tsuruta F, Masuyama N, Gotoh Y (2005) JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J Cell Biol 170, 295-304
16009721   Curated Info

3

Tsuruta F, et al. (2004) JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J 23, 1889-99
15071501   Curated Info