Tyr55
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Home > Phosphorylation Site Page: > Tyr55  -  TRIP6 (mouse)

Site Information
PLPPEHCyQPPGVPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456050

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 2 ) , Src iso1 (mouse) ( 1 )
Kinases, in vitro:
Src (human) ( 2 )
Treatments:
LPA ( 1 , 2 ) , PP2 ( 1 )

Downstream Regulation
Effects of modification on TRIP6:
intracellular localization ( 1 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )
Induce interaction with:
CRK (human) ( 2 ) , P130Cas (human) ( 2 )

References 

1

McMichael BK, Meyer SM, Lee BS (2010) c-Src-mediated phosphorylation of thyroid hormone receptor-interacting protein 6 (TRIP6) promotes osteoclast sealing zone formation. J Biol Chem 285, 26641-51
20547766   Curated Info

2

Lai YJ, Chen CS, Lin WC, Lin FT (2005) c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol Cell Biol 25, 5859-68
15988003   Curated Info