Tyr731
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Home > Phosphorylation Site Page: > Tyr731  -  CDH5 (mouse)

Site Information
PYDTLHIyGyEGAES   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456049

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 , 4 ) , mutation of modification site ( 4 , 5 ) , phospho-antibody ( 2 , 3 , 4 ) , phosphopeptide mapping ( 5 ) , western blotting ( 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:
cardiac-heart ( 2 ) , CHO (fibroblast) ( 5 ) , endothelial [CDH5 (mouse), genetic knockin] ( 4 ) , HLMVECs ( 3 ) , leukocyte [CDH5 (mouse), genetic knockin] ( 4 ) , lung ( 3 ) , microvessel endothelial-'brain, forebrain' ( 5 )

Upstream Regulation
Regulatory protein:
ANXA2 (mouse) ( 2 )
Treatments:
histamine ( 4 ) , PF-431396 ( 3 ) , PP1 ( 3 ) , vanadate ( 4 ) , VEGF ( 2 , 4 )

Downstream Regulation
Effects of modification on biological processes:
cell motility, altered ( 5 ) , endocytosis, inhibited ( 4 )

References 

1

Fu P, et al. (2020) Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation. J Biol Chem
32327488   Curated Info

2

Luo M, et al. (2017) Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases. J Exp Med 214, 2535-2545
28694388   Curated Info

3

Soni D, et al. (2017) Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca(2+) entry regulates disassembly of adherens junctions. Am J Physiol Lung Cell Mol Physiol 312, L1003-L1017
28385807   Curated Info

4

Wessel F, et al. (2014) Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin. Nat Immunol 15, 223-30
24487320   Curated Info

5

Turowski P, et al. (2008) Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration. J Cell Sci 121, 29-37
18096689   Curated Info