Tyr658
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Home > Phosphorylation Site Page: > Tyr658  -  CDH5 (mouse)

Site Information
GEMDTTSyDVSVLNs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456048

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 , 4 ) , phospho-antibody ( 1 , 2 , 3 ) , phosphopeptide mapping ( 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:
BAEC (endothelial) ( 2 ) , CHO (fibroblast) ( 4 ) , endothelial ( 2 , 3 ) , HLMVECs ( 1 ) , HUVEC (endothelial) ( 2 ) , microvessel endothelial-'brain, forebrain' ( 4 )

Upstream Regulation
Regulatory protein:
FAK (mouse) ( 3 ) , PLD2 (human) ( 1 ) , PLD2 (mouse) ( 1 )
Putative upstream phosphatases:
PTPN14 (human) ( 1 )
Treatments:
laminar flow ( 2 ) , LPS ( 1 ) , siRNA ( 1 ) , thrombin ( 1 ) , VU0364739 ( 1 )

Downstream Regulation
Effects of modification on CDH5:
activity, induced ( 3 ) , molecular association, regulation ( 2 ) , receptor recycling, induced ( 1 )
Induce interaction with:
GPSM2 (mouse) ( 2 )
Inhibit interaction with:
CTNND1 (mouse) ( 2 )

References 

1

Fu P, et al. (2020) Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation. J Biol Chem 295
32327488   Curated Info

2

Conway DE, et al. (2017) VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN. Curr Biol 27, 2219-2225.e5
28712573   Curated Info

3

Zhao X, et al. (2010) Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol 189, 955-65
20530207   Curated Info

4

Turowski P, et al. (2008) Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration. J Cell Sci 121, 29-37
18096689   Curated Info

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