Ser474
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Home > Phosphorylation Site Page: > Ser474  -  FOXM1 iso2 (human)

Site Information
PPLEEWPsPAPSFkE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 22648002

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , LN229 (glial) ( 1 )

Upstream Regulation
Regulatory protein:
axin 1 (human) ( 1 )
Putative in vivo kinases:
GSK3B (human) ( 1 )

Downstream Regulation
Effects of modification on FOXM1 iso2:
ubiquitination ( 1 )

References 

1

Chen Y, et al. (2016) Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation. EMBO J 35, 668-84
26912724   Curated Info

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