Ser288
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Home > Phosphorylation Site Page: > Ser288  -  CIITA (human)

Site Information
PDRPGsTsPFAPsAT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2286408

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 1 , 2 ) , HeLa (cervical) ( 2 ) , RAW 264 (macrophage) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 )
Kinases, in vitro:
ERK2 (human) ( 1 )
Treatments:
PD98059 ( 1 )

Downstream Regulation
Effects of modification on CIITA:
activity, inhibited ( 1 ) , intracellular localization ( 1 , 2 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, altered ( 1 , 2 )
Induce interaction with:
Exportin-1 (human) ( 1 )

References 

1

Voong LN, Slater AR, Kratovac S, Cressman DE (2008) Mitogen-activated Protein Kinase ERK1/2 Regulates the Class II Transactivator. J Biol Chem 283, 9031-9
18245089   Curated Info

2

Greer SF, et al. (2004) Serine residues 286, 288, and 293 within the CIITA: a mechanism for down-regulating CIITA activity through phosphorylation. J Immunol 173, 376-83
15210796   Curated Info