Ser892
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Home > Phosphorylation Site Page: > Ser892  -  IRS1 (human)

Site Information
LHPPEPKsPGEyVNI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456043

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 7 , 8 )
Disease tissue studied:
breast cancer ( 2 ) , breast ductal carcinoma ( 2 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 ) , type 2 diabetes ( 4 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 4 , 7 ) , 293 (epithelial) ( 8 ) , breast ( 1 , 2 ) , H2077 (pulmonary) ( 3 ) , H322M (pulmonary) ( 3 ) , HeLa (cervical) ( 5 )

Upstream Regulation
Treatments:
ischemia ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

4

Langlais P, et al. (2011) Global IRS-1 phosphorylation analysis in insulin resistance. Diabetologia 54, 2878-89
21850561   Curated Info

5

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

6

Langlais P, Mandarino LJ, Yi Z (2010) Label-free relative quantification of co-eluting isobaric phosphopeptides of insulin receptor substrate-1 by HPLC-ESI-MS/MS. J Am Soc Mass Spectrom 21, 1490-9
20594869   Curated Info

7

Yi Z, et al. (2007) Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle. Diabetes 56, 1508-16
17360977   Curated Info

8

Luo M, et al. (2005) Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223. Endocrinology 146, 4410-6
16020478   Curated Info