Thr174
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Home > Phosphorylation Site Page: > Thr174  -  BRSK2 (human)

Site Information
VGDSLLEtSCGSPHY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456031

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , peptide sequencing ( 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 1 ) , HEK293T (epithelial) ( 1 , 2 ) , HeLa (cervical) [LKB1 (human)] ( 3 ) , MEF (fibroblast) [LKB1 (human)] ( 3 )

Upstream Regulation
Regulatory protein:
ANK1 (human) ( 1 ) , ANK2 (human) ( 1 )
Kinases, in vitro:
LKB1 (human) ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )

References 

1

Di Meo D, et al. (2021) The balance of mitochondrial fission and fusion in cortical axons depends on the kinases SadA and SadB. Cell Rep 37, 110141
34936879   Curated Info

2

Nie J, et al. (2013) SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells. Mol Cell Biol 33, 2527-34
23629625   Curated Info

3

Lizcano JM, et al. (2004) LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 23, 833-43
14976552   Curated Info

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