Tyr72
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Home > Phosphorylation Site Page: > Tyr72  -  hnRNP K (human)

Site Information
IkALRTDyNAsVsVP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455999

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 3 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) [Src (human), transfection, Y527F constitutively active mutant] ( 2 ) , HeLa (cervical) ( 3 ) , PC9 (pulmonary) ( 1 ) , PC9-IR (pulmonary) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 2 , 3 )
Kinases, in vitro:
Src (human) ( 3 )

Downstream Regulation
Effects of modification on biological processes:
translation, altered ( 3 )

References 

1

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

2

Amanchy R, et al. (2008) Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays. J Proteome Res 7, 3900-10
18698806   Curated Info

3

Ostareck-Lederer A, et al. (2002) c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol 22, 4535-43
12052863   Curated Info

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