Ser437

Site Information
FSGELsWsADsIRLQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 455994

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:	2fTGH (fibroblast) ( 2 ) , E.coli (bacterial) ( 1 )

Downstream Regulation
Effects of modification on IRF5:	activity, induced ( 1 )
Effects of modification on biological processes:	transcription, induced ( 2 )

References
1	Chen W, et al. (2008) Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat Struct Mol Biol 15, 1213-20 18836453 Curated Info
2	Barnes BJ, Kellum MJ, Field AE, Pitha PM (2002) Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes. Mol Cell Biol 22, 5721-40 12138184 Curated Info