Ser241
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Home > Phosphorylation Site Page: > Ser241  -  pyrin (mouse)

Site Information
SGKKRPRsLEITTYS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455899

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 3 , 4 , 5 , 6 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
leukemia ( 5 ) , acute myelogenous leukemia ( 5 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , blood ( 5 ) , macrophage-bone marrow ( 2 ) , macrophage-peritoneum ( 4 ) , spleen ( 6 ) , stromal ( 3 )

Upstream Regulation
Treatments:
C. difficile Cytotoxin TcdA ( 2 ) , Clostridium_toxin_B ( 2 )

Downstream Regulation
Effects of modification on pyrin:
activity, inhibited ( 2 ) , molecular association, regulation ( 2 )
Induce interaction with:
14-3-3 epsilon (mouse) ( 2 )

References 

1

Malik HS, et al. (2023) Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes. mBio, e0206623
37787552   Curated Info

2

Gao W, et al. (2016) Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation. Proc Natl Acad Sci U S A 113, E4857-66
27482109   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

5

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

6

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

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