Ser205
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Home > Phosphorylation Site Page: > Ser205  -  pyrin (mouse)

Site Information
AQLRRNVsSAGRLQG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455897

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , macrophage-bone marrow ( 1 , 2 , 3 ) , neutrophil ( 2 )

Upstream Regulation
Putative upstream phosphatases:
PPP2CA (human) ( 1 ) , PPP2CB (human) ( 1 )
Treatments:
bacterial infection ( 1 , 2 ) , C. difficile Cytotoxin TcdA ( 3 ) , calyculin_A ( 1 ) , ciclosporin ( 1 ) , Clostridioides difficile toxin B ( 1 ) , Clostridium_toxin_B ( 2 , 3 ) , okadaic_acid ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on pyrin:
activity, inhibited ( 3 ) , molecular association, regulation ( 1 , 3 )
Induce interaction with:
14-3-3 epsilon (mouse) ( 3 ) , pyrin (human) ( 1 )

References 

1

Malik HS, et al. (2023) Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes. mBio, e0206623
37787552   Curated Info

2

Oh C, et al. (2022) Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins. Cell Rep 41, 111688
36417874   Curated Info

3

Gao W, et al. (2016) Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation. Proc Natl Acad Sci U S A 113, E4857-66
27482109   Curated Info

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