Ser140
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Home > Phosphorylation Site Page: > Ser140  -  E2A (mouse)

Site Information
LSsPGPLsPSGIKSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455905

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , electrophoretic mobility shift ( 4 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 4 )
Disease tissue studied:
anthrax infection ( 3 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 4 ) , C2C12 (myoblast) ( 4 ) , HEK293T (epithelial) ( 4 ) , macrophage-peritoneum ( 2 ) , spleen ( 3 )

Upstream Regulation
Regulatory protein:
MKK6 (mouse) ( 4 )
Putative in vivo kinases:
P38A (mouse) ( 4 )
Kinases, in vitro:
P38A (mouse) ( 4 )
Treatments:
SB203580 ( 4 ) , serum_withdrawal ( 4 )

Downstream Regulation
Effects of modification on E2A:
molecular association, regulation ( 4 )
Effects of modification on biological processes:
cell differentiation, altered ( 4 ) , transcription, altered ( 4 )
Induce interaction with:
MyoD (mouse) ( 4 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

3

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

4

LluĂ­s F, et al. (2005) E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription. EMBO J 24, 974-84
15719023   Curated Info