Ser234
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser234  -  rabphilin 3A (rat)

Site Information
GPPTRRAsEARMSTT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455904

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 3 ) , 'neuron, cerebellar granule'-brain ( 2 ) , 'neuron, hippocampal'-brain ( 3 ) , MIN6 (pancreatic) ( 1 ) , PC-12 (chromaffin) ( 1 )

Upstream Regulation
Regulatory protein:
MYRIP (human) ( 1 )
Kinases, in vitro:
PKACA (human) ( 3 ) , PKACA (rat) ( 2 ) , PKCA (human) ( 3 )
Treatments:
4-AP ( 4 ) , cAMP_analog ( 4 ) , colforsin ( 1 , 4 ) , depolarization ( 4 ) , exenatide ( 1 ) , glucose ( 1 ) , H-89 ( 2 ) , IBMX ( 1 , 4 ) , KT5720 ( 2 ) , low_Ca(2+) ( 4 ) , okadaic_acid ( 2 , 4 ) , phorbol_ester ( 4 ) , sphingosine_1-phosphate ( 4 ) , TEA ( 4 )

Downstream Regulation
Effects of modification on rabphilin 3A:
intracellular localization ( 1 , 4 )
Induce interaction with:
14-3-3 beta (mouse) ( 1 )

References 

1

Brozzi F, et al. (2012) MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway. Mol Biol Cell 23, 4444-55
22993210   Curated Info

2

Lonart G, S├╝dhof TC (2001) Characterization of rabphilin phosphorylation using phospho-specific antibodies. Neuropharmacology 41, 643-9
11640918   Curated Info

3

Foletti DL, Scheller RH (2001) Developmental regulation and specific brain distribution of phosphorabphilin. J Neurosci 21, 5461-72
11466417   Curated Info

4

Foletti DL, Blitzer JT, Scheller RH (2001) Physiological modulation of rabphilin phosphorylation. J Neurosci 21, 5473-83
11466418   Curated Info