Ser470
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Home > Phosphorylation Site Page: > Ser470  -  SYN3 (human)

Site Information
PQGQQPLsPQsGsPQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455901

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 4 ) , phospho-antibody ( 5 ) , western blotting ( 5 )
Disease tissue studied:
schizophrenia ( 4 )
Relevant cell line - cell type - tissue:
'brain, embryonic' ( 5 ) , 'neuron, hippocampal'-'brain, embryonic' ( 5 ) , blood ( 4 ) , brain ( 4 ) , NCI-H128 (pulmonary) ( 3 ) , NCI-H524 (pulmonary) ( 1 , 2 )

Upstream Regulation
Kinases, in vitro:
CDK1 (mouse) ( 5 ) , ERK1 (mouse) ( 5 )
Treatments:
neurotrophin-3 ( 5 ) , PD98059 ( 5 )

Disease / Diagnostics Relevance
Relevant diseases:
schizophrenia ( 4 )

References 

1

Possemato A (2006) CST Curation Set: 1729; Year: 2006; Biosample/Treatment: cell line, NCI-H524/0.5% serum; Disease: small-cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpSP, pSPX(K/R) Antibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb Cat#: 2325, PTMScan(R) Phospho-MAPK/CDK Substrate Motif (PXS*P, S*PXK/R) Immunoaffinity Beads Cat#: 1982
Curated Info

2

Possemato A (2006) CST Curation Set: 1730; Year: 2006; Biosample/Treatment: cell line, NCI-H524/0.5% serum; Disease: small-cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpSP, pSPX(K/R) Antibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb Cat#: 2325, PTMScan(R) Phospho-MAPK/CDK Substrate Motif (PXS*P, S*PXK/R) Immunoaffinity Beads Cat#: 1982
Curated Info

3

Possemato A (2006) CST Curation Set: 1732; Year: 2006; Biosample/Treatment: cell line, NCI-H128/0.5% serum; Disease: small-cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpSP, pSPX(K/R) Antibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb Cat#: 2325, PTMScan(R) Phospho-MAPK/CDK Substrate Motif (PXS*P, S*PXK/R) Immunoaffinity Beads Cat#: 1982
Curated Info

4

Lachman HM, Stopkova P, Rafael MA, Saito T (2005) Association of schizophrenia in African Americans to polymorphism in synapsin III gene. Psychiatr Genet 15, 127-32
15900227   Curated Info

5

Porton B, Ferreira A, DeLisi LE, Kao HT (2004) A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia. Biol Psychiatry 55, 118-25
14732590   Curated Info