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Site Information |
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SGKMRPRsLEVTIST SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 455899 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
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Downstream Regulation | |
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Effects of modification on pyrin: | |
Induce interaction with: |
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Relevant diseases: |
References | |
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Malik HS, et al. (2023) Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes. mBio, e0206623
37787552 Curated Info |
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Spel L, et al. (2022) CDC42 regulates PYRIN inflammasome assembly. Cell Rep 41, 111636
36384121 Curated Info |
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Mangan MSJ, et al. (2022) Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever. PLoS Biol 20, e3001351
36342970 Curated Info |
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Magnotti F, et al. (2022) Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism. Cell Rep 41, 111472
36223753 Curated Info |
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Park YH, Wood G, Kastner DL, Chae JJ (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17, 914-21
27270401 Curated Info |
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Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275 Curated Info |
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Masters SL, et al. (2016) Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. Sci Transl Med 8, 332ra45
27030597 Curated Info |
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Cobbold M, et al. (2013) MHC class I-associated phosphopeptides are the targets of memory-like immunity in leukemia. Sci Transl Med 5, 203ra125
24048523 Curated Info |
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Jéru I, et al. (2005) Interaction of pyrin with 14.3.3 in an isoform-specific and phosphorylation-dependent manner regulates its translocation to the nucleus. Arthritis Rheum 52, 1848-57
15934090 Curated Info |