Ser209

Site Information
RLRRNAssAGRLQGL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 455898

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 2 ) , macrophage-bone marrow ( 1 ) , mononuclear-blood ( 1 )

Downstream Regulation
Effects of modification on pyrin:	intracellular localization ( 2 ) , molecular association, regulation ( 2 )
Induce interaction with:	14-3-3 theta (human) ( 2 )

References
1	Park YH, Wood G, Kastner DL, Chae JJ (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17, 914-21 27270401 Curated Info
2	Jéru I, et al. (2005) Interaction of pyrin with 14.3.3 in an isoform-specific and phosphorylation-dependent manner regulates its translocation to the nucleus. Arthritis Rheum 52, 1848-57 15934090 Curated Info