Ser339
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Home > Phosphorylation Site Page: > Ser339  -  IRF3 (human)

Site Information
FTEGSGRsPRYALWF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2255400

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
IKKE (human) ( 2 ) , TBK1 (human) ( 2 )
Treatments:
LPS ( 2 ) , Newcastle_disease_virus ( 2 ) , poly(I-C) ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on IRF3:
molecular association, regulation ( 1 , 2 ) , protein degradation ( 1 , 2 )
Effects of modification on biological processes:
transcription, altered ( 2 )
Induce interaction with:
CBP (human) ( 1 ) , IRF3 (human) ( 1 ) , PIN1 (human) ( 2 )

References 

1

Clément JF, et al. (2008) Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol 82, 3984-96
18272581   Curated Info

2

Saitoh T, et al. (2006) Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat Immunol 7, 598-605
16699525   Curated Info