Tyr239
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Home > Phosphorylation Site Page: > Tyr239  -  SHC1 iso2 (mouse)

Site Information
EEPPDHQyyNDFPGK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448509

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 3 ) , mass spectrometry ( 4 , 7 ) , mutation of modification site ( 2 , 3 , 6 ) , phospho-antibody ( 5 ) , western blotting ( 2 , 3 , 5 )
Disease tissue studied:
breast cancer ( 6 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 7 ) , L3.6p1 (pancreatic) ( 2 ) , mammary gland ( 6 ) , MEF (fibroblast) [PTP1B (mouse), homozygous knockout] ( 4 ) , MEF (fibroblast) ( 4 , 5 ) , NMuMG (epithelial) ( 3 )

Upstream Regulation
Regulatory protein:
PAG (rat) ( 5 )
Treatments:
EGF ( 4 ) , PDGF ( 4 )

Downstream Regulation
Effects of modification on SHC1 iso2:
molecular association, regulation ( 6 ) , phosphorylation ( 6 )
Effects of modification on biological processes:
cell motility, altered ( 6 ) , cell motility, induced ( 3 , 6 )
Induce interaction with:
GRB2 (mouse) ( 6 )

Disease / Diagnostics Relevance
Relevant diseases:
lung cancer ( 3 )

References 

1

Kiepas A, et al. (2020) The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation. J Biol Chem
32299913   Curated Info

2

Huang H, et al. (2016) Up-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1. J Biol Chem 291, 23208-23223
27605668   Curated Info

3

Northey JJ, et al. (2013) Distinct Phosphotyrosine-dependent Functions of the ShcA Adaptor Protein Are Required for Transforming Growth Factor β (TGFβ)-induced Breast Cancer Cell Migration, Invasion, and Metastasis. J Biol Chem 288, 5210-22
23277357   Curated Info

4

Mertins P, et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics 7, 1763-77
18515860   Curated Info

5

Oneyama C, et al. (2008) The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src. Mol Cell 30, 426-36
18498747   Curated Info

6

Ursini-Siegel J, et al. (2008) ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J 27, 910-20
18273058   Curated Info

7

Moritz A (2003) CST Curation Set: 208; Year: 2003; Biosample/Treatment: cell line, 3T3/NRG1; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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