Ser96
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Home > Phosphorylation Site Page: > Ser96  -  Snail1 (human)

Site Information
TsLsDEDsGKGsQPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455883

In vivo Characterization
Methods used to characterize site in vivo:
microscopy-colocalization with upstream kinase ( 5 ) , mutation of modification site ( 4 , 5 ) , phospho-antibody ( 5 ) , western blotting ( 3 , 5 )
Disease tissue studied:
breast cancer ( 3 , 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 5 )
Kinases, in vitro:
GSK3B (human) ( 2 , 3 )
Putative upstream phosphatases:
CTDSP1 (human) ( 3 )
Phosphatases, in vitro:
CTDSP1 (human) ( 3 )

Downstream Regulation
Effects of modification on Snail1:
intracellular localization ( 3 ) , protein degradation ( 3 , 4 , 5 ) , ubiquitination ( 5 )
Effects of modification on biological processes:
cell motility, altered ( 3 ) , transcription, altered ( 3 )
Induce interaction with:
FBW1B (human) ( 5 )

References 

1

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

2

Xu Y, et al. (2010) Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. Oncogene 29, 3124-33
20305697   Curated Info

3

Wu Y, Evers BM, Zhou BP (2009) Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation. J Biol Chem 284, 640-8
19004823   Curated Info

4

Yook JI, et al. (2005) Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem 280, 11740-8
15647282   Curated Info

5

Zhou BP, et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6, 931-40
15448698   Curated Info