Ser107
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser107  -  Snail1 (human)

Site Information
sQPPsPPsPAPssFS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455882

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 3 ) , [32P] ATP in vitro ( 1 ) , [32P] bio-synthetic labeling ( 3 ) , immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry (in vitro) ( 1 ) , microscopy-colocalization with upstream kinase ( 6 ) , mutation of modification site ( 1 , 3 , 5 , 6 ) , phospho-antibody ( 6 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 , 4 , 6 )
Disease tissue studied:
breast cancer ( 1 , 4 , 6 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , ovarian cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
MKK6 (human) ( 1 )
Putative in vivo kinases:
GSK3B (human) ( 5 , 6 ) , P38A (human) ( 1 )
Kinases, in vitro:
CK1E (human) ( 2 ) , GSK3B (human) ( 4 , 5 ) , P38A (human) ( 1 )
Putative upstream phosphatases:
CTDSP1 (human) ( 4 )
Phosphatases, in vitro:
CTDSP1 (human) ( 4 )
Treatments:
cycloheximide ( 1 ) , EGF ( 1 ) , lithium ( 5 ) , MG132 ( 1 ) , SB203580 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on Snail1:
activity, induced ( 3 ) , enzymatic activity, induced ( 1 ) , intracellular localization ( 4 , 6 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein degradation ( 2 , 3 , 5 ) , protein stabilization ( 1 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell motility, altered ( 4 ) , cell motility, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, altered ( 3 , 4 ) , transcription, induced ( 1 )
Inhibit interaction with:
GSK3B (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
ovarian cancer ( 1 )

References 

1

Ryu KJ, et al. (2019) p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation that is Required for GSK3β-βTrCP-Induced Snail Degradation. Cancer Res
31209060   Curated Info

2

Xu Y, et al. (2010) Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. Oncogene 29, 3124-33
20305697   Curated Info

3

MacPherson MR, et al. (2010) Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. Mol Biol Cell 21, 244-53
19923321   Curated Info

4

Wu Y, Evers BM, Zhou BP (2009) Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation. J Biol Chem 284, 640-8
19004823   Curated Info

5

Yook JI, et al. (2005) Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem 280, 11740-8
15647282   Curated Info

6

Zhou BP, et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6, 931-40
15448698   Curated Info