Ser234
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Home > Phosphorylation Site Page: > Ser234  -  neurogenin 2 (mouse)

Site Information
SCTLsPAsPGSDVDy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2255100

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'brain, embryonic' ( 2 ) , 'neuron, cortical'-brain ( 1 ) , 'neuron, hippocampal'-brain ( 1 ) , 'stem, embryonic' ( 2 ) , HEK293T (epithelial) ( 2 )

Upstream Regulation
Regulatory protein:
DISC1 (mouse) ( 1 )
Putative in vivo kinases:
GSK3A (mouse) ( 2 ) , GSK3B (mouse) ( 2 )
Kinases, in vitro:
GSK3A (human) ( 2 ) , GSK3B (human) ( 2 )
Treatments:
GSK-3_inhibitor_X ( 2 ) , Shh ( 2 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on neurogenin 2:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell growth, altered ( 2 )
Induce interaction with:
LDB1 (mouse) ( 2 )

References 

1

Mao Y, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136, 1017-31
19303846   Curated Info

2

Ma YC, et al. (2008) Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron 58, 65-77
18400164   Curated Info