Ser104
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Home > Phosphorylation Site Page: > Ser104  -  Snail1 (human)

Site Information
GKGsQPPsPPsPAPs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455881

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 5 ) , [32P] ATP in vitro ( 1 ) , [32P] bio-synthetic labeling ( 5 ) , flow cytometry ( 2 ) , immunoprecipitation ( 2 , 3 ) , mutation of modification site ( 1 , 3 , 5 , 6 ) , phosphopeptide mapping ( 5 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
breast cancer ( 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
DYRK2 (human) ( 1 ) , P38A (human) ( 1 )
Putative in vivo kinases:
ERK2 (human) ( 3 ) , GSK3B (human) ( 6 )
Kinases, in vitro:
CK1E (human) ( 4 ) , DYRK2 (human) ( 1 ) , ERK2 (human) ( 3 ) , GSK3B (human) ( 6 )
Treatments:
collagen_I ( 3 ) , lithium ( 6 ) , PD98059 ( 3 ) , SB203580 ( 1 ) , siRNA ( 3 )

Downstream Regulation
Effects of modification on Snail1:
activity, induced ( 5 ) , intracellular localization ( 3 ) , protein degradation ( 4 , 5 , 6 ) , protein stabilization ( 3 ) , ubiquitination ( 4 )
Effects of modification on biological processes:
carcinogenesis, induced ( 3 ) , cell motility, induced ( 3 ) , transcription, altered ( 5 )

References 

1

Ryu KJ, et al. (2019) p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation that is Required for GSK3β-βTrCP-Induced Snail Degradation. Cancer Res
31209060   Curated Info

2

Lee JH, et al. (2017) A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1. Nat Cell Biol 19, 1260-1273
28892081   Curated Info

3

Zhang K, et al. (2013) The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol 15, 677-87
23644467   Curated Info

4

Xu Y, et al. (2010) Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. Oncogene 29, 3124-33
20305697   Curated Info

5

MacPherson MR, et al. (2010) Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. Mol Biol Cell 21, 244-53
19923321   Curated Info

6

Yook JI, et al. (2005) Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem 280, 11740-8
15647282   Curated Info