Ser1324

Site Information
PEVERRPsPHDEEEF SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 22547057

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 5 , 6 , 7 )
Disease tissue studied:	breast cancer ( 2 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , lung cancer ( 6 , 7 ) , non-small cell lung cancer ( 6 ) , melanoma skin cancer ( 3 )
Relevant cell line - cell type - tissue:	breast ( 1 ) , CL1-0 (pulmonary) ( 7 ) , CL1-1 (pulmonary) ( 7 ) , CL1-2 (pulmonary) ( 7 ) , CL1-5 (pulmonary) ( 7 ) , H2077 (pulmonary) ( 6 ) , H322M (pulmonary) ( 6 ) , MCF-7 (breast cell) ( 2 ) , SH-SY5Y (neural crest) [LRRK2 (human), transfection, over-expression of LRRK2(G2019S)] ( 5 ) , SH-SY5Y (neural crest) ( 5 ) , WM239A (melanocyte) ( 3 )

Upstream Regulation
Treatments:	LRRK2-IN-1 ( 5 ) , metastatic potential ( 7 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Carrier M, et al. (2016) Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines. PLoS One 11, e0157290 27362937 Curated Info
3	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
4	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
5	Luerman GC, et al. (2014) Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. J Neurochem 128, 561-76 24117733 Curated Info
6	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
7	Wang YT, et al. (2010) An informatics-assisted label-free quantitation strategy that depicts phosphoproteomic profiles in lung cancer cell invasion. J Proteome Res 9, 5582-97 20815410 Curated Info