Ser73
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Home > Phosphorylation Site Page: > Ser73  -  Chk2 (human)

Site Information
VstQELYsIPEDQEP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2251701

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 2 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HT1080 (fibroblast) ( 2 )

Upstream Regulation
Kinases, in vitro:
PLK3 (human) ( 2 )

Downstream Regulation
Effects of modification on Chk2:
enzymatic activity, induced ( 2 ) , molecular association, regulation ( 2 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 )

References 

1

King JB, et al. (2007) Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom 21, 3443-51
17918214   Curated Info

2

Bahassi el M, et al. (2006) Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. Mutat Res 596, 166-76
16481012   Curated Info

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