Ser1403
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Home > Phosphorylation Site Page: > Ser1403  -  ATM (human)

Site Information
CHkTKLKsILEILSk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 22496700

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
ataxia-telangiectasia ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurB (human) ( 1 )
Kinases, in vitro:
AurB (human) ( 1 )
Treatments:
hesperadin ( 1 ) , ionizing_radiation ( 1 ) , nocodazole ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on ATM:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

Yang C, et al. (2011) Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint. Mol Cell 44, 597-608
22099307   Curated Info